Drug interactions
Methadone + Tinidazole
Severity: Minor
Methadone and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tinidazole is partly metabolised by CYP3A4, and methadone has little inhibitory effect on this enzyme, so a meaningful rise in tinidazole levels is unlikely. The only plausible concern is that tinidazole could theoretically affect methadone, but this is not well documented.
What this interaction means in plain words
Methadone and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methadone belongs to Musculoskeletal; Tinidazole belongs to Anti Parasitic.
Why it happens
No established mechanism; methadone is a weak CYP3A4 substrate and not a significant inhibitor.
What to do
No routine action is required. Be alert for opioid-related adverse effects or reduced tinidazole efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Methadone with Tinidazole?
MediHelp rates the interaction as minor. Methadone and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tinidazole is partly metabolised by CYP3A4, and methadone has little inhibitory effect on this enzyme, so a meaningful rise in tinidazole levels is unlikely. The only plausible concern is that tinidazole could theoretically affect methadone, but this is not well documented.
How serious is the interaction between Methadone and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required. Be alert for opioid-related adverse effects or reduced tinidazole efficacy.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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