Drug interactions
Methocarbamol + Nortriptyline
Severity: Moderate
Methocarbamol and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and nortriptyline also has anticholinergic effects, so the combination may increase drowsiness, dizziness and confusion. Older patients are at particular risk of falls and cognitive impairment.
What this interaction means in plain words
Methocarbamol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methocarbamol belongs to Musculoskeletal; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Monitor for oversedation and anticholinergic effects, especially in older adults. Reduce the dose of methocarbamol if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Methocarbamol with Nortriptyline?
MediHelp rates the interaction as moderate. Methocarbamol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and nortriptyline also has anticholinergic effects, so the combination may increase drowsiness, dizziness and confusion. Older patients are at particular risk of falls and cognitive impairment.
How serious is the interaction between Methocarbamol and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, especially in older adults. Reduce the dose of methocarbamol if drowsiness is troublesome.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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