Drug interactions
Methocarbamol + Oxazepam
Severity: Moderate
Methocarbamol and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxazepam is a benzodiazepine and methocarbamol is a sedating muscle relaxant, so together they can cause greater drowsiness, impaired coordination and slowed psychomotor function. Falls and accidents are a particular concern in older patients.
What this interaction means in plain words
Methocarbamol and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methocarbamol belongs to Musculoskeletal; Oxazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Use the lowest effective doses for the shortest duration and counsel against driving or alcohol. Reduce the dose of either drug if sedation or unsteadiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Methocarbamol with Oxazepam?
MediHelp rates the interaction as moderate. Methocarbamol and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxazepam is a benzodiazepine and methocarbamol is a sedating muscle relaxant, so together they can cause greater drowsiness, impaired coordination and slowed psychomotor function. Falls and accidents are a particular concern in older patients.
How serious is the interaction between Methocarbamol and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and counsel against driving or alcohol. Reduce the dose of either drug if sedation or unsteadiness develops.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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