Drug interactions
Methocarbamol + Sodium oxybate
Severity: Major
Methocarbamol and Sodium oxybate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium oxybate is a potent CNS depressant, and methocarbamol adds further sedation. Profound sedation, respiratory depression, coma and death can result.
What this interaction means in plain words
Methocarbamol and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methocarbamol belongs to Musculoskeletal; Sodium oxybate belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression through pharmacodynamic synergism.
What to do
Avoid if possible by using a non-sedating alternative to methocarbamol. If unavoidable, use minimum doses and duration and monitor closely for respiratory depression and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methocarbamol
Other interactions of Sodium oxybate
- Alprazolam + Sodium oxybate Contraindicated
- Amobarbital + Sodium oxybate Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Methocarbamol with Sodium oxybate?
MediHelp rates the interaction as major. Methocarbamol and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sodium oxybate is a potent CNS depressant, and methocarbamol adds further sedation. Profound sedation, respiratory depression, coma and death can result.
How serious is the interaction between Methocarbamol and Sodium oxybate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible by using a non-sedating alternative to methocarbamol. If unavoidable, use minimum doses and duration and monitor closely for respiratory depression and sedation.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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