Drug interactions
Methohexital + Nortriptyline
Severity: Moderate
Methohexital and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combining them can cause deeper or prolonged sedation and respiratory depression. Tricyclics can also lower the seizure threshold and cause hypotension during anesthesia.
What this interaction means in plain words
Methohexital and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular effects.
What to do
Titrate methohexital carefully and ensure airway and hemodynamic monitoring. Inform the anesthesia team of tricyclic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Nortriptyline?
MediHelp rates the interaction as moderate. Methohexital and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combining them can cause deeper or prolonged sedation and respiratory depression. Tricyclics can also lower the seizure threshold and cause hypotension during anesthesia.
How serious is the interaction between Methohexital and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and ensure airway and hemodynamic monitoring. Inform the anesthesia team of tricyclic use.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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