Drug interactions
Methohexital + Oxazepam
Severity: Moderate
Methohexital and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital, a barbiturate anesthetic, adds to the sedative and respiratory depressant effects of oxazepam. This may cause deeper than expected sedation, hypotension, and apnea.
What this interaction means in plain words
Methohexital and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Reduce methohexital dose as needed and titrate to effect with continuous monitoring of oxygenation and ventilation. Ensure airway support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methohexital and Oxazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Oxazepam?
MediHelp rates the interaction as moderate. Methohexital and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital, a barbiturate anesthetic, adds to the sedative and respiratory depressant effects of oxazepam. This may cause deeper than expected sedation, hypotension, and apnea.
How serious is the interaction between Methohexital and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce methohexital dose as needed and titrate to effect with continuous monitoring of oxygenation and ventilation. Ensure airway support is available.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
