Drug interactions
Methotrexate + Osimertinib
Severity: Moderate
Methotrexate and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib inhibits BCRP, which contributes to methotrexate elimination. Methotrexate exposure may increase and cause more toxicity.
What this interaction means in plain words
Methotrexate and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Osimertinib belongs to Oncology.
Why it happens
BCRP inhibition may reduce methotrexate efflux.
What to do
Monitor blood counts and renal and hepatic function. Reduce the methotrexate dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Methotrexate with Osimertinib?
MediHelp rates the interaction as moderate. Methotrexate and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib inhibits BCRP, which contributes to methotrexate elimination. Methotrexate exposure may increase and cause more toxicity.
How serious is the interaction between Methotrexate and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal and hepatic function. Reduce the methotrexate dose if toxicity occurs.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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