Drug interactions
Methotrexate + Rilonacept
Severity: Moderate
Methotrexate and Rilonacept: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks IL-1 and may increase infection susceptibility, and together with methotrexate immunosuppression may be greater. Myelosuppression from methotrexate adds to this risk.
What this interaction means in plain words
Methotrexate and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression from IL-1 blockade and antimetabolite activity.
What to do
Monitor for signs of infection and follow blood counts. Interrupt rilonacept during serious infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Methotrexate with Rilonacept?
MediHelp rates the interaction as moderate. Methotrexate and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks IL-1 and may increase infection susceptibility, and together with methotrexate immunosuppression may be greater. Myelosuppression from methotrexate adds to this risk.
How serious is the interaction between Methotrexate and Rilonacept?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and follow blood counts. Interrupt rilonacept during serious infection.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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