Drug interactions
Methotrexate + Tafamidis
Severity: Moderate
Methotrexate and Tafamidis: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and may increase methotrexate exposure. This could heighten methotrexate toxicity, though clinical data are limited.
What this interaction means in plain words
Methotrexate and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Tafamidis belongs to Cardiovascular.
Why it happens
Inhibition of BCRP efflux transport reduces methotrexate elimination and raises exposure.
What to do
Monitor blood counts and liver and renal function. Reduce the methotrexate dose if signs of toxicity develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methotrexate and Tafamidis, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
- Rosuvastatin + Tafamidis Moderate
Frequently asked questions
Can I take Methotrexate with Tafamidis?
MediHelp rates the interaction as moderate. Methotrexate and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafamidis inhibits BCRP in vitro and may increase methotrexate exposure. This could heighten methotrexate toxicity, though clinical data are limited.
How serious is the interaction between Methotrexate and Tafamidis?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver and renal function. Reduce the methotrexate dose if signs of toxicity develop.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
