Drug interactions
Rosuvastatin + Tafamidis
Severity: Moderate
Rosuvastatin and Tafamidis: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro, and rosuvastatin is a BCRP substrate. Rosuvastatin exposure rises with tafamidis, which can increase the risk of statin-related muscle effects.
What this interaction means in plain words
Rosuvastatin and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Tafamidis belongs to Cardiovascular.
Why it happens
Tafamidis inhibits intestinal and hepatic BCRP, reducing rosuvastatin efflux.
What to do
Monitor for myopathy symptoms and consider the lowest effective rosuvastatin dose. Check creatine kinase if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Rosuvastatin with Tafamidis?
MediHelp rates the interaction as moderate. Rosuvastatin and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafamidis inhibits BCRP in vitro, and rosuvastatin is a BCRP substrate. Rosuvastatin exposure rises with tafamidis, which can increase the risk of statin-related muscle effects.
How serious is the interaction between Rosuvastatin and Tafamidis?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy symptoms and consider the lowest effective rosuvastatin dose. Check creatine kinase if symptoms develop.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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