Drug interactions
Atorvastatin + Tafamidis
Severity: Moderate
Atorvastatin and Tafamidis: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and may raise exposure to BCRP substrates such as atorvastatin. Higher statin exposure can increase the risk of myopathy, although the clinical effect is expected to be modest.
What this interaction means in plain words
Atorvastatin and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Tafamidis belongs to Cardiovascular.
Why it happens
Tafamidis inhibits breast cancer resistance protein (BCRP), decreasing intestinal and hepatic efflux of atorvastatin.
What to do
Monitor for muscle symptoms and check creatine kinase if they occur. Reduce the atorvastatin dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atorvastatin and Tafamidis, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
- Rosuvastatin + Tafamidis Moderate
Frequently asked questions
Can I take Atorvastatin with Tafamidis?
MediHelp rates the interaction as moderate. Atorvastatin and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafamidis inhibits BCRP in vitro and may raise exposure to BCRP substrates such as atorvastatin. Higher statin exposure can increase the risk of myopathy, although the clinical effect is expected to be modest.
How serious is the interaction between Atorvastatin and Tafamidis?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and check creatine kinase if they occur. Reduce the atorvastatin dose if adverse effects emerge.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
