Drug interactions
Rivaroxaban + Tafamidis
Severity: Moderate
Rivaroxaban and Tafamidis: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis may increase rivaroxaban exposure through BCRP inhibition. This is a predicted effect and may raise the risk of bleeding.
What this interaction means in plain words
Rivaroxaban and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivaroxaban belongs to Cardiovascular; Tafamidis belongs to Cardiovascular.
Why it happens
Tafamidis inhibits BCRP-mediated efflux of rivaroxaban.
What to do
Monitor for bleeding and consider reassessing the rivaroxaban dose. Check renal function and other interacting drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rosuvastatin + Tafamidis Moderate
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Rivaroxaban with Tafamidis?
MediHelp rates the interaction as moderate. Rivaroxaban and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafamidis may increase rivaroxaban exposure through BCRP inhibition. This is a predicted effect and may raise the risk of bleeding.
How serious is the interaction between Rivaroxaban and Tafamidis?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider reassessing the rivaroxaban dose. Check renal function and other interacting drugs.
What other medicines interact with Tafamidis?
MediHelp also lists interactions of Tafamidis with, for example, Apixaban, Atorvastatin, Methotrexate. The full list is on the Tafamidis page.
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