Drug interactions
Methotrexate + Trofinetide
Severity: Moderate
Methotrexate and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, and these transporters take up methotrexate into the liver. Inhibition could raise methotrexate exposure and risk of toxicity, although clinical data are limited.
What this interaction means in plain words
Methotrexate and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake may reduce methotrexate clearance.
What to do
Monitor blood counts, liver and renal function when combined. Consider lowering the methotrexate dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Methotrexate with Trofinetide?
MediHelp rates the interaction as moderate. Methotrexate and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, and these transporters take up methotrexate into the liver. Inhibition could raise methotrexate exposure and risk of toxicity, although clinical data are limited.
How serious is the interaction between Methotrexate and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver and renal function when combined. Consider lowering the methotrexate dose if toxicity develops.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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