Drug interactions
Methoxsalen + Minocycline
Severity: Moderate
Methoxsalen and Minocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both minocycline and methoxsalen can cause photosensitivity. Combined use may increase phototoxic reactions to sunlight or UVA exposure.
What this interaction means in plain words
Methoxsalen and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Minocycline belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic photosensitizing effects.
What to do
Advise strict sun avoidance and photoprotection, and adjust UV exposure if phototoxicity appears. Consider an alternative antibiotic during PUVA if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Minocycline?
MediHelp rates the interaction as moderate. Methoxsalen and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both minocycline and methoxsalen can cause photosensitivity. Combined use may increase phototoxic reactions to sunlight or UVA exposure.
How serious is the interaction between Methoxsalen and Minocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun avoidance and photoprotection, and adjust UV exposure if phototoxicity appears. Consider an alternative antibiotic during PUVA if feasible.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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