Drug interactions
Methoxsalen + Promethazine
Severity: Moderate
Methoxsalen and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is a recognized photosensitizing drug and methoxsalen is used to induce photosensitivity in PUVA therapy. Together they may increase the risk of exaggerated phototoxic reactions such as severe erythema and burns after UVA exposure.
What this interaction means in plain words
Methoxsalen and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Promethazine belongs to Respiratory.
Why it happens
Additive photosensitizing (phototoxic) effects.
What to do
Avoid starting promethazine during PUVA therapy where possible, or reduce the UVA dose and monitor skin closely. Counsel patients on strict sun protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Promethazine?
MediHelp rates the interaction as moderate. Methoxsalen and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine is a recognized photosensitizing drug and methoxsalen is used to induce photosensitivity in PUVA therapy. Together they may increase the risk of exaggerated phototoxic reactions such as severe erythema and burns after UVA exposure.
How serious is the interaction between Methoxsalen and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting promethazine during PUVA therapy where possible, or reduce the UVA dose and monitor skin closely. Counsel patients on strict sun protection.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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