Drug interactions
Methoxsalen + Tetracycline
Severity: Moderate
Methoxsalen and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause photosensitivity, and together they may increase the risk of phototoxic reactions such as severe sunburn or blistering after UV exposure. This is particularly relevant during PUVA therapy.
What this interaction means in plain words
Methoxsalen and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Tetracycline belongs to Anti Bacterial.
Why it happens
Additive phototoxic effects of two photosensitizing agents.
What to do
Counsel on strict sun protection and avoid excess UV exposure. Consider an alternative antibiotic and adjust UV dosing during PUVA.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Tetracycline?
MediHelp rates the interaction as moderate. Methoxsalen and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause photosensitivity, and together they may increase the risk of phototoxic reactions such as severe sunburn or blistering after UV exposure. This is particularly relevant during PUVA therapy.
How serious is the interaction between Methoxsalen and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on strict sun protection and avoid excess UV exposure. Consider an alternative antibiotic and adjust UV dosing during PUVA.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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