Drug interactions
Methoxyflurane + Oxaliplatin
Severity: Moderate
Methoxyflurane and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride ions that can be nephrotoxic, and oxaliplatin can occasionally affect renal function. Combined use could add to the risk of kidney injury, although low analgesic doses of methoxyflurane lessen the concern.
What this interaction means in plain words
Methoxyflurane and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from fluoride metabolites of methoxyflurane and platinum-related renal toxicity.
What to do
Use the lowest effective methoxyflurane dose, avoid repeated dosing, and monitor renal function in patients with reduced kidney function or other nephrotoxins.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Methoxyflurane with Oxaliplatin?
MediHelp rates the interaction as moderate. Methoxyflurane and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxyflurane releases fluoride ions that can be nephrotoxic, and oxaliplatin can occasionally affect renal function. Combined use could add to the risk of kidney injury, although low analgesic doses of methoxyflurane lessen the concern.
How serious is the interaction between Methoxyflurane and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective methoxyflurane dose, avoid repeated dosing, and monitor renal function in patients with reduced kidney function or other nephrotoxins.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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