Drug interactions
Methscopolamine + Perphenazine
Severity: Moderate
Methscopolamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methscopolamine is a quaternary antimuscarinic with limited CNS entry, but it adds peripheral anticholinergic effects to perphenazine. Dry mouth, constipation, urinary retention, blurred vision and tachycardia may be amplified.
What this interaction means in plain words
Methscopolamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive peripheral antimuscarinic effects.
What to do
Monitor for urinary retention, constipation and other anticholinergic effects, especially in older patients. Reduce the dose or change therapy if symptoms are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Methscopolamine with Perphenazine?
MediHelp rates the interaction as moderate. Methscopolamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methscopolamine is a quaternary antimuscarinic with limited CNS entry, but it adds peripheral anticholinergic effects to perphenazine. Dry mouth, constipation, urinary retention, blurred vision and tachycardia may be amplified.
How serious is the interaction between Methscopolamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and other anticholinergic effects, especially in older patients. Reduce the dose or change therapy if symptoms are troublesome.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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