Drug interactions
Methyl aminolevulinate + Perphenazine
Severity: Moderate
Methyl aminolevulinate and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a phenothiazine that can cause photosensitivity, which may add to the phototoxic reaction of methyl aminolevulinate photodynamic therapy. This can lead to more intense local skin reactions.
What this interaction means in plain words
Methyl aminolevulinate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitization.
What to do
Check the skin and inform the patient about photoprotection and the expected local reaction. Consider deferring treatment or monitoring closely for severe reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Methyl aminolevulinate with Perphenazine?
MediHelp rates the interaction as moderate. Methyl aminolevulinate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a phenothiazine that can cause photosensitivity, which may add to the phototoxic reaction of methyl aminolevulinate photodynamic therapy. This can lead to more intense local skin reactions.
How serious is the interaction between Methyl aminolevulinate and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the skin and inform the patient about photoprotection and the expected local reaction. Consider deferring treatment or monitoring closely for severe reactions.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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