Drug interactions
Methyl aminolevulinate + Piroxicam
Severity: Moderate
Methyl aminolevulinate and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyl aminolevulinate is used with light in photodynamic therapy and drugs that cause photosensitivity may amplify skin reactions. Piroxicam is a recognized photosensitizing NSAID, making additive reactions plausible. Systemic exposure from topical methyl aminolevulinate is low.
What this interaction means in plain words
Methyl aminolevulinate and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive photosensitization in treated skin.
What to do
Consider avoiding piroxicam around photodynamic therapy, using a non-photosensitizing analgesic instead. Monitor the treated area for exaggerated erythema or pain and advise light protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Methyl aminolevulinate with Piroxicam?
MediHelp rates the interaction as moderate. Methyl aminolevulinate and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyl aminolevulinate is used with light in photodynamic therapy and drugs that cause photosensitivity may amplify skin reactions. Piroxicam is a recognized photosensitizing NSAID, making additive reactions plausible. Systemic exposure from topical methyl aminolevulinate is low.
How serious is the interaction between Methyl aminolevulinate and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider avoiding piroxicam around photodynamic therapy, using a non-photosensitizing analgesic instead. Monitor the treated area for exaggerated erythema or pain and advise light protection.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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