Drug interactions
Methylenedioxymethamphetamine + Midazolam
Severity: Moderate
Methylenedioxymethamphetamine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a stimulant that may mask midazolam sedation, but it also causes hyperthermia, tachycardia and hypertension. Benzodiazepines are sometimes used to treat MDMA toxicity, and sedation can hide worsening clinical signs.
What this interaction means in plain words
Methylenedioxymethamphetamine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects; MDMA serotonergic and sympathomimetic stimulation versus GABAergic depression.
What to do
Monitor temperature, heart rate, blood pressure and mental state; titrate midazolam to effect rather than fixed doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methylenedioxymethamphetamine and Midazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Midazolam?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a stimulant that may mask midazolam sedation, but it also causes hyperthermia, tachycardia and hypertension. Benzodiazepines are sometimes used to treat MDMA toxicity, and sedation can hide worsening clinical signs.
How serious is the interaction between Methylenedioxymethamphetamine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor temperature, heart rate, blood pressure and mental state; titrate midazolam to effect rather than fixed doses.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
