Drug interactions
Mavacamten + Modafinil
Severity: Major
Mavacamten and Modafinil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared mainly by CYP2C19 with CYP3A4 contribution, and exposure changes can cause loss of efficacy or excessive negative inotropy leading to systolic heart failure. Modafinil has mixed effects, inducing CYP3A4 and inhibiting CYP2C19, making the net exposure unpredictable.
What this interaction means in plain words
Mavacamten and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil inhibits CYP2C19 and induces CYP3A4, altering mavacamten metabolism in opposing directions.
What to do
Avoid the combination where possible; if used, monitor LVEF and clinical status closely and adjust mavacamten dose by echocardiographic guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Modafinil
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Modafinil?
MediHelp rates the interaction as major. Mavacamten and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is cleared mainly by CYP2C19 with CYP3A4 contribution, and exposure changes can cause loss of efficacy or excessive negative inotropy leading to systolic heart failure. Modafinil has mixed effects, inducing CYP3A4 and inhibiting CYP2C19, making the net exposure unpredictable.
How serious is the interaction between Mavacamten and Modafinil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor LVEF and clinical status closely and adjust mavacamten dose by echocardiographic guidance.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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