Drug interactions
Lenacapavir + Modafinil
Severity: Major
Lenacapavir and Modafinil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak to moderate CYP3A4 inducer and may lower lenacapavir concentrations. Subtherapeutic antiviral exposure risks loss of virologic control and resistance.
What this interaction means in plain words
Lenacapavir and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lenacapavir belongs to Anti Virals; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil induces CYP3A4, increasing the metabolism of lenacapavir.
What to do
Avoid combining; lenacapavir labeling advises against moderate CYP3A inducers. Consider an alternative wakefulness agent without enzyme induction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Modafinil
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Modafinil?
MediHelp rates the interaction as major. Lenacapavir and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil is a weak to moderate CYP3A4 inducer and may lower lenacapavir concentrations. Subtherapeutic antiviral exposure risks loss of virologic control and resistance.
How serious is the interaction between Lenacapavir and Modafinil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; lenacapavir labeling advises against moderate CYP3A inducers. Consider an alternative wakefulness agent without enzyme induction.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Leniolisib, Lorlatinib, Lumateperone. The full list is on the Modafinil page.
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