Drug interactions
Methylergonovine + Nitroglycerin
Severity: Major
Methylergonovine and Nitroglycerin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is a vasoconstrictor that can oppose nitroglycerin's effects and precipitate coronary vasospasm or ischemia. Nitrates may also raise ergot exposure. Use is of concern in patients with coronary disease.
What this interaction means in plain words
Methylergonovine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic opposition between ergot vasoconstriction and nitrate vasodilation.
What to do
Avoid where an alternative uterotonic is feasible in patients with coronary disease. If used, monitor blood pressure, ECG and chest pain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Frequently asked questions
Can I take Methylergonovine with Nitroglycerin?
MediHelp rates the interaction as major. Methylergonovine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylergonovine is a vasoconstrictor that can oppose nitroglycerin's effects and precipitate coronary vasospasm or ischemia. Nitrates may also raise ergot exposure. Use is of concern in patients with coronary disease.
How serious is the interaction between Methylergonovine and Nitroglycerin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where an alternative uterotonic is feasible in patients with coronary disease. If used, monitor blood pressure, ECG and chest pain.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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