Drug interactions
Methylergonovine + Perphenazine
Severity: Moderate
Methylergonovine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is an ergot derivative with serotonergic activity, and perphenazine blocks dopamine D2 receptors. Co-administration could theoretically contribute to serotonin toxicity or neuroleptic malignant syndrome, although clinical reports are scarce. Methylergonovine is usually given for short periods postpartum, which limits exposure.
What this interaction means in plain words
Methylergonovine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical additive serotonergic activity combined with dopamine blockade; no firmly established mechanism.
What to do
Monitor for hyperthermia, rigidity, agitation, tremor and autonomic instability during co-administration. Stop methylergonovine and treat if signs of serotonin toxicity or neuroleptic malignant syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Methylergonovine with Perphenazine?
MediHelp rates the interaction as moderate. Methylergonovine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylergonovine is an ergot derivative with serotonergic activity, and perphenazine blocks dopamine D2 receptors. Co-administration could theoretically contribute to serotonin toxicity or neuroleptic malignant syndrome, although clinical reports are scarce. Methylergonovine is usually given for short periods postpartum, which limits exposure.
How serious is the interaction between Methylergonovine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, agitation, tremor and autonomic instability during co-administration. Stop methylergonovine and treat if signs of serotonin toxicity or neuroleptic malignant syndrome appear.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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