Drug interactions
Methylergonovine + Zolmitriptan
Severity: Contraindicated
Methylergonovine and Zolmitriptan: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine can cause strong arterial constriction, and zolmitriptan adds further vasoconstrictor activity. The combination may cause prolonged vasospasm and ischemia.
What this interaction means in plain words
Methylergonovine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction through 5-HT1B/1D agonism and ergot adrenergic and serotonergic effects.
What to do
Do not co-administer, and separate doses by at least 24 hours. Use a non-ergot uterotonic where bleeding control is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Methylergonovine with Zolmitriptan?
MediHelp rates the interaction as contraindicated. Methylergonovine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylergonovine can cause strong arterial constriction, and zolmitriptan adds further vasoconstrictor activity. The combination may cause prolonged vasospasm and ischemia.
How serious is the interaction between Methylergonovine and Zolmitriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and separate doses by at least 24 hours. Use a non-ergot uterotonic where bleeding control is needed.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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