Drug interactions
Methylphenidate + Rasagiline
Severity: Contraindicated
Methylphenidate and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate releases and blocks reuptake of catecholamines, while MAO inhibition prevents their breakdown. Together they can cause a sudden, severe rise in blood pressure, a hypertensive crisis. Labeling for methylphenidate prohibits use during MAOI therapy and for 14 days after stopping an MAOI.
What this interaction means in plain words
Methylphenidate and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methylphenidate belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition increases stores of norepinephrine and dopamine, which methylphenidate then enhances through release and reuptake blockade, causing exaggerated pressor responses.
What to do
Do not co-administer, and allow at least 14 days after stopping rasagiline before starting methylphenidate. Choose a non-stimulant alternative if ADHD treatment is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Safinamide Contraindicated
- Methylphenidate + Selegiline Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Methylphenidate with Rasagiline?
MediHelp rates the interaction as contraindicated. Methylphenidate and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylphenidate releases and blocks reuptake of catecholamines, while MAO inhibition prevents their breakdown. Together they can cause a sudden, severe rise in blood pressure, a hypertensive crisis. Labeling for methylphenidate prohibits use during MAOI therapy and for 14 days after stopping an MAOI.
How serious is the interaction between Methylphenidate and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and allow at least 14 days after stopping rasagiline before starting methylphenidate. Choose a non-stimulant alternative if ADHD treatment is needed.
What other medicines interact with Methylphenidate?
MediHelp also lists interactions of Methylphenidate with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methylphenidate page.
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