Drug interactions
Methylphenidate + Procarbazine
Severity: Contraindicated
Methylphenidate and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting activity, and MAOIs combined with methylphenidate can cause hypertensive crisis. Labeling for methylphenidate contraindicates use with MAOIs or within 14 days of stopping them.
What this interaction means in plain words
Methylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methylphenidate belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition by procarbazine leads to excess catecholamine accumulation, exaggerating methylphenidate's sympathomimetic effect.
What to do
Avoid the combination and do not give methylphenidate within 14 days of procarbazine. Use a non-stimulant alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
- Methylphenidate + Selegiline Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Methylphenidate with Procarbazine?
MediHelp rates the interaction as contraindicated. Methylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has monoamine oxidase inhibiting activity, and MAOIs combined with methylphenidate can cause hypertensive crisis. Labeling for methylphenidate contraindicates use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Methylphenidate and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and do not give methylphenidate within 14 days of procarbazine. Use a non-stimulant alternative.
What other medicines interact with Methylphenidate?
MediHelp also lists interactions of Methylphenidate with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methylphenidate page.
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