Drug reference
methylphenidate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (CNS Stimulants)
Mechanism of action
Unknown; may block reuptake of norepinephrine and dopamine into presynaptic neurons; may stimulate CNS similar to amphetamines; may stimulate cerebral cortex and subcortical structures
Common side effects
- Insomnia
- Decreased appetite
- Upper abdominal pain
- Affect lability
- Decreased weight
Known interactions (7)
- isocarboxazid + methylphenidate Contraindicated
- ergotamine + methylphenidate Major
- cabergoline + methylphenidate Moderate
- Fluvoxamine + methylphenidate Moderate
- Lamotrigine + methylphenidate Moderate
- Levothyroxine + methylphenidate Moderate
- methylphenidate + Valproic acid Moderate
Related conditions
Frequently asked questions
What drug class is methylphenidate?
methylphenidate belongs to: Central Nervous System.
How does methylphenidate work?
Unknown; may block reuptake of norepinephrine and dopamine into presynaptic neurons; may stimulate CNS similar to amphetamines; may stimulate cerebral cortex and subcortical structures
What are the common side effects of methylphenidate?
Insomnia, Decreased appetite, Upper abdominal pain, Affect lability, Decreased weight
Which drugs interact with methylphenidate?
isocarboxazid, ergotamine, cabergoline, Fluvoxamine, Lamotrigine, Levothyroxine, Valproic acid
Full monographs, dosing and an interaction checker in the MediHelp app
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