Drug interactions
Methylphenidate + Sacubitril / valsartan
Severity: Moderate
Methylphenidate and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate can increase blood pressure and heart rate, which may offset the blood pressure lowering of sacubitril/valsartan. Control of hypertension or heart failure may be affected.
What this interaction means in plain words
Methylphenidate and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between sympathomimetic pressor effects and angiotensin receptor and neprilysin blockade.
What to do
Monitor blood pressure and heart failure status when methylphenidate is started or adjusted. Adjust cardiovascular therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Methylphenidate with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Methylphenidate and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate can increase blood pressure and heart rate, which may offset the blood pressure lowering of sacubitril/valsartan. Control of hypertension or heart failure may be affected.
How serious is the interaction between Methylphenidate and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart failure status when methylphenidate is started or adjusted. Adjust cardiovascular therapy if control is lost.
What other medicines interact with Methylphenidate?
MediHelp also lists interactions of Methylphenidate with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methylphenidate page.
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