Drug interactions
Methylphenidate + Selegiline transdermal
Severity: Contraindicated
Methylphenidate and Selegiline transdermal: contraindicated interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a monoamine oxidase inhibitor, and transdermal delivery gives systemic MAO inhibition at antidepressant doses. With methylphenidate, accumulated catecholamines can trigger hypertensive crisis. Labeling prohibits methylphenidate during MAOI treatment and for 14 days after stopping.
What this interaction means in plain words
Methylphenidate and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition prevents catecholamine breakdown, potentiating the norepinephrine and dopamine release and reuptake blockade caused by methylphenidate.
What to do
Do not coadminister; separate by at least 14 days after stopping the MAOI before starting methylphenidate. Use a non-MAOI alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Methylphenidate with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Methylphenidate and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is a monoamine oxidase inhibitor, and transdermal delivery gives systemic MAO inhibition at antidepressant doses. With methylphenidate, accumulated catecholamines can trigger hypertensive crisis. Labeling prohibits methylphenidate during MAOI treatment and for 14 days after stopping.
How serious is the interaction between Methylphenidate and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; separate by at least 14 days after stopping the MAOI before starting methylphenidate. Use a non-MAOI alternative.
What other medicines interact with Methylphenidate?
MediHelp also lists interactions of Methylphenidate with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methylphenidate page.
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