Drug interactions
Methyltestosterone + Tacrolimus
Severity: Moderate
Methyltestosterone and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens such as methyltestosterone may raise tacrolimus concentrations. Higher levels raise the risk of nephrotoxicity, neurotoxicity and hyperglycemia.
What this interaction means in plain words
Methyltestosterone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP3A4-mediated tacrolimus metabolism by androgens.
What to do
Check tacrolimus trough levels and renal function after starting or stopping methyltestosterone, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Methyltestosterone with Tacrolimus?
MediHelp rates the interaction as moderate. Methyltestosterone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens such as methyltestosterone may raise tacrolimus concentrations. Higher levels raise the risk of nephrotoxicity, neurotoxicity and hyperglycemia.
How serious is the interaction between Methyltestosterone and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels and renal function after starting or stopping methyltestosterone, and adjust the tacrolimus dose accordingly.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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