Drug interactions
Metipranolol + Metoprolol
Severity: Moderate
Metipranolol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol is an ophthalmic non-selective beta-blocker that can be absorbed systemically. Combined with oral metoprolol it may cause additive bradycardia, hypotension or bronchospasm.
What this interaction means in plain words
Metipranolol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic blockade from systemic absorption of ophthalmic metipranolol.
What to do
Monitor heart rate and blood pressure, and consider a non-beta-blocker glaucoma agent if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metipranolol with Metoprolol?
MediHelp rates the interaction as moderate. Metipranolol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metipranolol is an ophthalmic non-selective beta-blocker that can be absorbed systemically. Combined with oral metoprolol it may cause additive bradycardia, hypotension or bronchospasm.
How serious is the interaction between Metipranolol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and consider a non-beta-blocker glaucoma agent if effects occur.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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