Drug interactions
Metoclopramide intranasal + Midazolam
Severity: Moderate
Metoclopramide intranasal and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has central dopamine-blocking and sedating effects that may add to benzodiazepine-induced drowsiness and psychomotor impairment. Metoclopramide can also speed gastric emptying and so alter the absorption of orally given midazolam. The clinical significance is usually modest.
What this interaction means in plain words
Metoclopramide intranasal and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, plus possible pharmacokinetic change through altered gastric motility.
What to do
Monitor for excessive sedation and consider a lower midazolam dose when the two are used together. Counsel patients to avoid driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Midazolam?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide has central dopamine-blocking and sedating effects that may add to benzodiazepine-induced drowsiness and psychomotor impairment. Metoclopramide can also speed gastric emptying and so alter the absorption of orally given midazolam. The clinical significance is usually modest.
How serious is the interaction between Metoclopramide intranasal and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider a lower midazolam dose when the two are used together. Counsel patients to avoid driving or operating machinery.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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