Drug interactions
Metoclopramide intranasal + Mirabegron
Severity: Moderate
Metoclopramide intranasal and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and can raise metoclopramide concentrations. Higher exposure increases the risk of extrapyramidal symptoms, tardive dyskinesia and sedation, and the fixed intranasal dose cannot be reduced.
What this interaction means in plain words
Metoclopramide intranasal and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mirabegron inhibits CYP2D6, reducing metoclopramide metabolism.
What to do
Monitor for extrapyramidal symptoms and sedation, or use an oral metoclopramide formulation allowing dose reduction. Consider an alternative antiemetic or prokinetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Metoclopramide intranasal with Mirabegron?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirabegron is a moderate CYP2D6 inhibitor and can raise metoclopramide concentrations. Higher exposure increases the risk of extrapyramidal symptoms, tardive dyskinesia and sedation, and the fixed intranasal dose cannot be reduced.
How serious is the interaction between Metoclopramide intranasal and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation, or use an oral metoclopramide formulation allowing dose reduction. Consider an alternative antiemetic or prokinetic.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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