Drug interactions
Metoclopramide intranasal + Nabilone
Severity: Moderate
Metoclopramide intranasal and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and CNS effects. Metoclopramide may also cause extrapyramidal and psychiatric effects, and nabilone can cause dizziness, mood changes and dysphoria, so the combination may worsen CNS toxicity.
What this interaction means in plain words
Metoclopramide intranasal and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for sedation, dizziness, agitation and movement disorders. Choose another antiemetic combination if CNS adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Frequently asked questions
Can I take Metoclopramide intranasal with Nabilone?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and CNS effects. Metoclopramide may also cause extrapyramidal and psychiatric effects, and nabilone can cause dizziness, mood changes and dysphoria, so the combination may worsen CNS toxicity.
How serious is the interaction between Metoclopramide intranasal and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness, agitation and movement disorders. Choose another antiemetic combination if CNS adverse effects emerge.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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