Drug interactions
Metoclopramide intranasal + Pentazocine
Severity: Moderate
Metoclopramide intranasal and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness and extrapyramidal effects, and opioids may antagonise its prokinetic effect on gastric motility. Combined use may increase sedation and dizziness while reducing antiemetic and prokinetic benefit.
What this interaction means in plain words
Metoclopramide intranasal and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects and opposing effects on gastrointestinal motility via opioid receptors versus dopamine antagonism.
What to do
Monitor for excess sedation and reduced gastric emptying; consider a different antiemetic if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Metoclopramide intranasal with Pentazocine?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness and extrapyramidal effects, and opioids may antagonise its prokinetic effect on gastric motility. Combined use may increase sedation and dizziness while reducing antiemetic and prokinetic benefit.
How serious is the interaction between Metoclopramide intranasal and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduced gastric emptying; consider a different antiemetic if sedation is troublesome.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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