Drug interactions
Metoclopramide intranasal + Sirolimus
Severity: Moderate
Metoclopramide intranasal and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying and may increase the absorption of sirolimus, producing higher blood concentrations. Raised levels can increase the risk of sirolimus toxicity such as hyperlipidemia, cytopenias and impaired wound healing.
What this interaction means in plain words
Metoclopramide intranasal and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enhanced gastrointestinal motility increases the rate and extent of sirolimus absorption.
What to do
Monitor sirolimus trough concentrations when metoclopramide is started or stopped. Adjust the sirolimus dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Sirolimus?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide speeds gastric emptying and may increase the absorption of sirolimus, producing higher blood concentrations. Raised levels can increase the risk of sirolimus toxicity such as hyperlipidemia, cytopenias and impaired wound healing.
How serious is the interaction between Metoclopramide intranasal and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when metoclopramide is started or stopped. Adjust the sirolimus dose according to levels.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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