Drug interactions
Metoclopramide intranasal + Succinylcholine
Severity: Moderate
Metoclopramide intranasal and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can prolong the neuromuscular blockade of succinylcholine, delaying recovery. This is reported mainly with systemic metoclopramide and may be less relevant with intranasal use.
What this interaction means in plain words
Metoclopramide intranasal and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Metoclopramide inhibits plasma cholinesterase, reducing succinylcholine metabolism.
What to do
Monitor neuromuscular function with a nerve stimulator and expect prolonged blockade. Reduce the succinylcholine dose if needed and maintain ventilatory support until recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Metoclopramide intranasal with Succinylcholine?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can prolong the neuromuscular blockade of succinylcholine, delaying recovery. This is reported mainly with systemic metoclopramide and may be less relevant with intranasal use.
How serious is the interaction between Metoclopramide intranasal and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and expect prolonged blockade. Reduce the succinylcholine dose if needed and maintain ventilatory support until recovery.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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