Drug interactions
Metoclopramide intranasal + Tacrolimus
Severity: Moderate
Metoclopramide intranasal and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying and can increase tacrolimus absorption, leading to higher blood concentrations. This may increase tacrolimus toxicity such as nephrotoxicity and tremor.
What this interaction means in plain words
Metoclopramide intranasal and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enhanced gastric motility accelerates tacrolimus delivery to the absorptive site, raising bioavailability.
What to do
Monitor tacrolimus trough levels when metoclopramide is started or stopped and adjust the tacrolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Metoclopramide intranasal with Tacrolimus?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide speeds gastric emptying and can increase tacrolimus absorption, leading to higher blood concentrations. This may increase tacrolimus toxicity such as nephrotoxicity and tremor.
How serious is the interaction between Metoclopramide intranasal and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels when metoclopramide is started or stopped and adjust the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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