Drug interactions
Metoclopramide intranasal + Tizanidine
Severity: Moderate
Metoclopramide intranasal and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is a dopamine antagonist that can cause drowsiness and extrapyramidal effects, and tizanidine causes sedation. Additive CNS effects are possible, but the interaction is not well characterised.
What this interaction means in plain words
Metoclopramide intranasal and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable additive CNS depression; the mechanism is not firmly established.
What to do
Monitor for increased drowsiness and warn the patient about driving or operating machinery. Reduce doses if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Metoclopramide intranasal with Tizanidine?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is a dopamine antagonist that can cause drowsiness and extrapyramidal effects, and tizanidine causes sedation. Additive CNS effects are possible, but the interaction is not well characterised.
How serious is the interaction between Metoclopramide intranasal and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and warn the patient about driving or operating machinery. Reduce doses if excess sedation occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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