Drug interactions
Metoprolol + Pirbuterol
Severity: Moderate
Metoprolol and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol blocks beta receptors and may reduce the bronchodilator effect of pirbuterol. Although it is beta-1 selective, selectivity is dose-dependent and bronchospasm may occur in susceptible patients.
What this interaction means in plain words
Metoprolol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta adrenergic receptors, with loss of selectivity at higher metoprolol doses.
What to do
Use the lowest effective metoprolol dose in patients with airway disease and monitor respiratory symptoms and bronchodilator response. Consider non-beta-blocker alternatives if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Pirbuterol?
MediHelp rates the interaction as moderate. Metoprolol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol blocks beta receptors and may reduce the bronchodilator effect of pirbuterol. Although it is beta-1 selective, selectivity is dose-dependent and bronchospasm may occur in susceptible patients.
How serious is the interaction between Metoprolol and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective metoprolol dose in patients with airway disease and monitor respiratory symptoms and bronchodilator response. Consider non-beta-blocker alternatives if control worsens.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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