Drug interactions
Metoprolol + Quinacrine
Severity: Moderate
Metoprolol and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6 and thereby raise metoprolol concentrations. Increased bradycardia, hypotension and fatigue are possible, though clinical data are limited.
What this interaction means in plain words
Metoprolol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Predicted inhibition of CYP2D6-mediated metoprolol metabolism.
What to do
Monitor heart rate and blood pressure when starting quinacrine. Reduce the metoprolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Quinacrine?
MediHelp rates the interaction as moderate. Metoprolol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6 and thereby raise metoprolol concentrations. Increased bradycardia, hypotension and fatigue are possible, though clinical data are limited.
How serious is the interaction between Metoprolol and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting quinacrine. Reduce the metoprolol dose if bradycardia or hypotension occurs.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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