Drug interactions
Metoprolol + Sacubitril / valsartan
Severity: Moderate
Metoprolol and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol and sacubitril/valsartan are commonly combined in heart failure, and the combination is beneficial. Additive blood pressure lowering can cause hypotension, dizziness and renal effects, particularly during initiation or titration.
What this interaction means in plain words
Metoprolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects of beta-blockade and neprilysin/angiotensin receptor blockade.
What to do
Monitor blood pressure, renal function and potassium during initiation and titration. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Metoprolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol and sacubitril/valsartan are commonly combined in heart failure, and the combination is beneficial. Additive blood pressure lowering can cause hypotension, dizziness and renal effects, particularly during initiation or titration.
How serious is the interaction between Metoprolol and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium during initiation and titration. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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