Drug interactions
Metoprolol + Salsalate
Severity: Minor
Metoprolol and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate with relatively weak effects on renal prostaglandins, so interference with metoprolol is probably small. Blood pressure may rise slightly during sustained high-dose use.
What this interaction means in plain words
Metoprolol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild prostaglandin inhibition causing sodium and fluid retention that can oppose the antihypertensive effect.
What to do
Monitor blood pressure if salsalate is used regularly at high doses. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Salsalate?
MediHelp rates the interaction as minor. Metoprolol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is a non-acetylated salicylate with relatively weak effects on renal prostaglandins, so interference with metoprolol is probably small. Blood pressure may rise slightly during sustained high-dose use.
How serious is the interaction between Metoprolol and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if salsalate is used regularly at high doses. No routine dose change is needed.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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