Drug interactions
Metoprolol + Sodium citrate / citric acid
Severity: Minor
Metoprolol and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate-containing alkalinizing solutions may marginally change gastric pH and metoprolol absorption. Any clinical effect is expected to be minimal.
What this interaction means in plain words
Metoprolol and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Altered gastric pH may slightly affect metoprolol absorption.
What to do
Separate administration by about 2 hours where convenient. No routine monitoring is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Metoprolol and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate-containing alkalinizing solutions may marginally change gastric pH and metoprolol absorption. Any clinical effect is expected to be minimal.
How serious is the interaction between Metoprolol and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by about 2 hours where convenient. No routine monitoring is required.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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