Drug interactions
Metoprolol + Thiothixene
Severity: Moderate
Metoprolol and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol and thiothixene may raise each other's concentrations and add hypotensive effects. This can cause bradycardia, orthostatic hypotension, or increased antipsychotic effects.
What this interaction means in plain words
Metoprolol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible competition for hepatic metabolism (CYP2D6) plus additive hypotensive effects.
What to do
Monitor blood pressure and heart rate, and reduce the dose of either drug if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Thiothixene?
MediHelp rates the interaction as moderate. Metoprolol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol and thiothixene may raise each other's concentrations and add hypotensive effects. This can cause bradycardia, orthostatic hypotension, or increased antipsychotic effects.
How serious is the interaction between Metoprolol and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and reduce the dose of either drug if hypotension or bradycardia occurs.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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