Drug interactions
Metreleptin + Repaglinide
Severity: Moderate
Metreleptin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metreleptin improves insulin sensitivity, and combined with insulin secretagogues such as repaglinide it can lead to hypoglycemia. The risk is greatest in patients with lipodystrophy who are already on antidiabetic therapy.
What this interaction means in plain words
Metreleptin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metreleptin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effect from improved insulin sensitivity plus increased insulin secretion.
What to do
Monitor blood glucose closely when starting metreleptin and reduce the repaglinide dose proactively if needed. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Metreleptin
Frequently asked questions
Can I take Metreleptin with Repaglinide?
MediHelp rates the interaction as moderate. Metreleptin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin improves insulin sensitivity, and combined with insulin secretagogues such as repaglinide it can lead to hypoglycemia. The risk is greatest in patients with lipodystrophy who are already on antidiabetic therapy.
How serious is the interaction between Metreleptin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting metreleptin and reduce the repaglinide dose proactively if needed. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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