Drug interactions
Metronidazole + Piroxicam
Severity: Minor
Metronidazole and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may slightly raise piroxicam levels, potentially increasing NSAID adverse effects. Clinical consequences are expected to be small and are poorly documented.
What this interaction means in plain words
Metronidazole and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Piroxicam belongs to Musculoskeletal.
Why it happens
Metronidazole may weakly inhibit CYP2C9 metabolism of piroxicam.
What to do
No specific adjustment is needed. Be alert for gastrointestinal symptoms during extended co-treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Piroxicam?
MediHelp rates the interaction as minor. Metronidazole and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole may slightly raise piroxicam levels, potentially increasing NSAID adverse effects. Clinical consequences are expected to be small and are poorly documented.
How serious is the interaction between Metronidazole and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed. Be alert for gastrointestinal symptoms during extended co-treatment.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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