Drug interactions
Metronidazole + Solifenacin
Severity: Minor
Metronidazole and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole has been described as a weak CYP3A4 inhibitor and may modestly raise solifenacin exposure. Metronidazole itself has a minor QT liability. The clinical effect is generally small.
What this interaction means in plain words
Metronidazole and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Solifenacin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4 metabolism of solifenacin, with possible minor additive QT effects.
What to do
No dose change is normally needed; monitor for anticholinergic adverse effects during a metronidazole course. Check an ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Solifenacin?
MediHelp rates the interaction as minor. Metronidazole and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole has been described as a weak CYP3A4 inhibitor and may modestly raise solifenacin exposure. Metronidazole itself has a minor QT liability. The clinical effect is generally small.
How serious is the interaction between Metronidazole and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for anticholinergic adverse effects during a metronidazole course. Check an ECG if other QT-prolonging risk factors are present.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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